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Pharmaceutical Anastrozole Arimidex Anti Estrogen Hormones Powder Antineoplastic Raw Materials

Quick Detail:

1, Manufacturer :TOP STEROIDS

2, Alias: Anastrozole Arimidex

3, Purity:99%min

4, Character: White crystalline powder.

5, Usage: An aromatase inhibitor. Used as an antineoplastic raw materials.

Potent selective triazole aromatase inhibitors, can inhibit the cytochrome P-450 aromatase enzyme which depends blocking the biosynthesis of estrogen, and estrogen to stimulate breast cancer cell growth factors. Treatment of breast cancer, especially for those with hormone relapse after adjuvant therapy after menopause for women with advanced breast cancer.

Description:

Arimidex (anastrozole) is the aromatase inhibitor of choice. Arimidex’s mechanism of action — blocking conversion of aromatizable steroids to estrogen — is in contrast to the mechanism of action of anti-estrogens such as clomiphene (Clomid) or tamoxifen (Nolvadex), which block estrogen receptors in some tissues, and activate estrogen receptors in others.

Applications:

Anastrozole Arimidex Antiestrogens steroids powder

The drug is appropriately used when using substantial amounts of aromatizing steroids, or when one is prone to gynecomastia and using moderate amounts of such steroids. Arimidex does not have the side effects of aminoglutethimide (Cytadren) and can achieve a high degree of estrogen blockade, much moreso than Cytadren. It is possible to reduce estrogen too much with Arimidex, and for this reason blood tests, or less preferably salivary tests, should be taken after the first week of use to determine if the dosing is correct.

Specifications :

Items	Standard	Results
Description	White crystalline powder	Complies
Identification	IR HPLC Reactive	Conform with standard IR Conform with standard HPLC Conform
Solubility	Freely soluble in methanol,acetone,ethanol and tetrahydrofuran.And very soluble in acetonitrile	Complies
Total Impurity	max.0.5%	0.18%
Total Unspecified Impurity	max. 0.2%	0.08%
Individual unspecified impurlty	max. 0.1%	0.05%
Related compound B	max. 0.2%	0.07%
Related compound C	max. 0.2%	0.04%
Related compound D	max. 0.1%	0.05%
Related compound E	max. 0.1%	0.06%
Limit of cyclohexane	max. 0.08%	ND
Limit of ethylacetate	max. 0.1%	0.07%
Melting point	81.0~84.0℃	82.5～83.2℃
Water	max. 0.3%	0.21%
Residue on ignition	max. 0.1%	0.07%
Heavy Metals	max.0.001%	Complies
Assay(HPLC)	98.0%～102.0%	99.8%
Storage	Cool and dry
Conclusion	It complies to USP32 .

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