Hot sale N-Acetylneuraminic acid CAS#131-48-6

Product description


Product Description





Description

Hot Supply N-Methyl-D-Aspartic acid !

N-Methyl-D-Aspartic acid (NMDA) is a synthetic agonist of the NMDA receptor that mimics the binding action of the endogenous ligand glutamate. The NMDA receptor is a voltage-gated ion channel closely involved in memory, in spatial learning and perturbing the normal behavior of this receptor system with NMDA exposure has facilitated elucidation of NMDA receptor-mediated activities.

NMDA is a glutamate-like excitatory substance and is a particularly potent excitant. NMDA binds to NMDA-receptor and interacts with it. This interaction causes a conformational change in the receptor or associated membrane molecules, which opened pores to allow extracellular sodium ions to flow down their electrochemical gradient and depolarise the cell. However, NMDA is proved to be a poor substrate for the uptake transporters, suggesting that the excitatory effect could not be an indirect consequence of glutamate uptake. Besides that, NMDA is found to increase intracellular calcium and release arachidonic acid, both of which generate oxygen radicals, subsequently inducing neuronal death.
Typical Specifation
Awell Ingredients Co.,Ltd.
Product Name
N-Acetylneuraminic acid
CAS No.
131-48-6
Chemical Structure
C11H19NO9
Formula Weight
309.27
Packing
1kg/bag or 25kg/Drum with PE bag liner
Shelf Life
2 Years
Appearance
White crystalline powder
Assay
98.0%
Specific rotation
-30.0~34.0
Water
≤5%
Total plate count
≤1000cfu/g
Heavy Metals
≤10ppm
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