Hyaluronic Aicd (also called hyaluronic acid or hyaluronate or HA) is an anionic, non sulfated glycosaminoglycan distributed widely throughout connective, epithelial, and neural tissues. It is unique among glycosaminoglycans in that it is nonsulfated, forms in the plasma membrane instead of the Golgi, and can be very large, with its molecular weight often reaching the millions. One of the chief

components of the extracellular matrix, hyaluronan contributes significantly to cell proliferation and migration