Name	Cyclosporin A
Synonyms	Antibiotic S 7481F1; Cyclosporine
Molecular Formula	C62H111N11O12
Molecular Weight	1202.62
CAS Registry Number	59865-13-3

White crystalline powder

Loss on dying≤2.0%

Heavy metals≤0.002%

Individual  impurity≤0.7%

Total impurity≤1.5%

Any other impurity≤0.1%

Acetone≤0.5%

Ethanol≤0.5%

Acetic acid≤0.5%

Ethyl acetate≤0.5%

Assay:98.5~101.5%

Cyclosporin A is a lipophilic cyclic peptide compounds separated by certain Hyphomycetes fungi, such as Cylindrocarpon lucidum and Tolypocladium inflatumculture medium. In 1980s, as an immunosuppressant, it has been widely used in the world, is now used for a variety of tissues and organ transplant to prevent rejection reaction and to treat autoimmune diseases. 

Cyclosporin A is a strong immunosuppressant, inhibits the onset of the reaction in cell media, reversibly inhibits T cell proliferation, does not inhibit the generation of blood cells, does not affect the function of the phagocyte. As compared with other inhibitors, fewer advantages are induce or aggravate infection, mainly used in clinical kidney, liver, heart, lung, bone marrow transplant anti-rejection, can be combined with adrenal corticosteroids, but not in combination with other immunosuppressive agents. Also used in certain autoimmune diseases (such as systemic lupus erythematosus, lupus nephritis, rheumatoid arthritis, autoimmune hemolytic anemia). Try to uveitis, severe aplastic anemia, refractory idiopathic thrombocytopenic purpura, psoriasis, etc.