Name	Trilostane
Synonyms	(4a,5a,17b)-3,17-Dihydroxy-4,5-epoxyandrost-2-ene-2-carbonitrile
Molecular Formula	C20H27NO3
Molecular Weight	329.43
CAS Registry Number	13647-35-3
EINECS	237-133-0

White to pale white powder

Loss on drying≤0.5%

Melting point:257°C to 270°C

Specific rotation:+137° to +139

Residue on ignition≤0.10%

Related impurities≤1.0%

Residue solvent≤0.5%

Heavy metals≤20ppm

Assay≥99.0%

Trilostane is an inhibitor of 3β-hydroxysteroid dehydrogenase used in the treatment of Cushing's syndrome and primary hyperaldosteronism. These are both disorders where excess amounts of corticosteroid hormones are produced in the body. Corticosteroids are essential for the body to make use of carbohydrates, fats and proteins and for a normal response to stress. They are also necessary for the regulation of salt and water balance in the body. Trilostane helps prevent the production of corticosteroids, controlling the symptoms associated with these disorders. 

Trilostane can also be useful in the treatment of breast cancer that has relapsed in women who have gone through menopause.